Modulation of the vault protein-protein interaction for tuning of molecular release

• Main Authors: Yu, Kang, Yau, Yin Hoe, Sinha, Ameya, Tan, Tabitha, Kickhoefer, Valerie A., Rome, Leonard H., Lee, Hwankyu, Shochat, Susana G., Lim, Sierin
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Molecular Release; Vault; DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/88105; http://hdl.handle.net/10220/45629
• Institution: Nanyang Technological University

Vaults are naturally occurring ovoid nanoparticles constructed from a protein shell that is composed of multiple copies of major vault protein (MVP). The vault-interacting domain of vault poly(ADP-ribose)-polymerase (INT) has been used as a shuttle to pack biomolecular cargo in the vault lumen. Howe...