Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress

• Main Authors: Li, Liang, Chan, Jeremy Soon Kiat, Tan, Ming Jie, Sng, Ming Keat, Teo, Ziqiang, Phua, Terri, Choo, Chee Chong, Zhu, Pengcheng, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cancer-associated Fibroblasts; DRNTU::Science::Biological sciences; Oxidative Stress
• Online Access: https://hdl.handle.net/10356/88547; http://hdl.handle.net/10220/45798
• Institution: Nanyang Technological University

Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic re...