Asymmetric dimethylarginine in adult falciparum malaria: relationships with disease severity, antimalarial treatment, hemolysis, and inflammation

• Main Authors: Barber, Bridget E., William, Timothy, Grigg, Matthew J., Parameswaran, Uma, Piera, Kim A., Yeo, Tsin Wen, Anstey, Nicholas M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Arginine; DRNTU::Science::Medicine; ADMA
• Online Access: https://hdl.handle.net/10356/89025; http://hdl.handle.net/10220/46994
• Institution: Nanyang Technological University

Background: Endothelial nitric oxide (NO) bioavailability is impaired in severe falciparum malaria (SM). Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase (NOS), contributes to endothelial dysfunction and is associated with mortality in adults with falciparum malaria. Howeve...