Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

• Main Authors: Ng, Benjamin S. H., Shyu Jr., Peter, Ho, Nurulain, Chaw, Ruijie, Seah, Yi Ling, Marvalim, Charlie, Thibault, Guillaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences; Endoplasmic Reticulum; Phospholipids
• Online Access: https://hdl.handle.net/10356/89646; http://hdl.handle.net/10220/49317
• Institution: Nanyang Technological University

Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. Phospholipid perturbation has been associated to cellular stress responses. However, in most cases, the implication of membrane lipid changes to homeostatic cellular r...