Establishing a genetically engineered mouse ES cell line expressing an inducible Xist transgene along chromosome 19

Xist (X-inactive specific transcript) RNA plays an important role in X chromosome inactivation (XCI), a dosage compensation mechanism mammalian females have evolved to transcriptionally silence one of two copies of X chromosomes they carry. Xist RNA remains in the nucleus, and during XCI onset, it i...

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Bibliographic Details
Main Author: Tan, Christina En Hui
Other Authors: Francesc Xavier Roca Castella
Format: Theses and Dissertations
Language:English
Published: 2018
Subjects:
Online Access:https://hdl.handle.net/10356/89676
http://hdl.handle.net/10220/46341
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Institution: Nanyang Technological University
Language: English

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