Establishing a genetically engineered mouse ES cell line expressing an inducible Xist transgene along chromosome 19

• المؤلف الرئيسي: Tan, Christina En Hui
• مؤلفون آخرون: Francesc Xavier Roca Castella
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2018
• الموضوعات: DRNTU::Science::Biological sciences::Genetics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89676; http://hdl.handle.net/10220/46341

Xist (X-inactive specific transcript) RNA plays an important role in X chromosome inactivation (XCI), a dosage compensation mechanism mammalian females have evolved to transcriptionally silence one of two copies of X chromosomes they carry. Xist RNA remains in the nucleus, and during XCI onset, it i...