Mode of heparin attachment to nanocrystalline hydroxyapatite affects its interaction with bone morphogenetic protein-2

• Main Authors: Goonasekera, Chandhi S., Jack, Kevin S., Bhakta, Gajadhar, Rai, Bina, Luong-Van, Emma, Nurcombe, Victor, Cool, Simon M., Cooper-White, Justin J., Grøndahl, Lisbeth
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Medicine; Heparin; Bone Morphogenetic Protein 2
• Online Access: https://hdl.handle.net/10356/89942; http://hdl.handle.net/10220/46465
• Institution: Nanyang Technological University

Heparin has a high affinity for bone morphogenetic protein-2 (BMP-2), which is a key growth factor in bone regeneration. The aim of this study was to investigate how the rate of release of BMP-2 was affected when adsorbed to nanosized hydroxyapatite (HAP) particles functionalized with heparin by dif...