Molecular features underlying neurodegeneration identified through in vitro modeling of genetically diverse parkinson’s disease patients

• Main Authors: Lin, Lin, Göke, Jonathan, Cukuroglu, Engin, Dranias, Mark R., VanDongen, Antonius M.J., Stanton, Lawrence W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Alternative RNA Splicing; Article
• Online Access: https://hdl.handle.net/10356/89993; http://hdl.handle.net/10220/46469
• Institution: Nanyang Technological University

The fact that Parkinson’s disease (PD) can arise from numerous genetic mutations suggests a unifying molecular pathology underlying the various genetic backgrounds. To address this hypothesis, we took an integrated approach utilizing in vitro disease modeling and comprehensive transcriptome profilin...