Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3

• Main Authors: Funston, Garth., Goh, Walter., Wei, Siau Jia., Tng, Quah Soo., Tong, Loh Jiah., Verma, Chandra Shekhar., Ghadessy, Farid., Lane, David P., Brown, Christopher J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/95362; http://hdl.handle.net/10220/9204
• Institution: Nanyang Technological University

Translationally Controlled Tumour Protein (TCTP), a highly conserved protein present in all eukaryotic organisms, has a number of intracellular and extracellular functions including an anti-apoptotic role. TCTP was recently shown to interact with both p53 and HDM2, inhibiting auto-ubiquitination of...