C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature
Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good...
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sg-ntu-dr.10356-958532022-02-16T16:29:18Z C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature Isley, Nicholas A. Lipshutz, Bruce H. Huang, Shenlin Leong, Wendy Wen Yi Zhong, Guofu School of Physical and Mathematical Sciences Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed. 2013-07-12T03:22:41Z 2019-12-06T19:22:20Z 2013-07-12T03:22:41Z 2019-12-06T19:22:20Z 2012 2012 Journal Article Lipshutz, B. H., Huang, S., Leong, W. W. Y., Zhong, G., & Isley, N. A. (2012). C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature. Journal of the American Chemical Society, 134(49), 19985-19988. https://hdl.handle.net/10356/95853 http://hdl.handle.net/10220/11287 10.1021/ja309409e 23190029 en Journal of the American chemical society © 2012 American Chemical Society. |
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Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Isley, Nicholas A. Lipshutz, Bruce H. Huang, Shenlin Leong, Wendy Wen Yi Zhong, Guofu |
| format |
Article |
| author |
Isley, Nicholas A. Lipshutz, Bruce H. Huang, Shenlin Leong, Wendy Wen Yi Zhong, Guofu |
| spellingShingle |
Isley, Nicholas A. Lipshutz, Bruce H. Huang, Shenlin Leong, Wendy Wen Yi Zhong, Guofu C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| author_sort |
Isley, Nicholas A. |
| title |
C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| title_short |
C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| title_full |
C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| title_fullStr |
C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| title_full_unstemmed |
C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| title_sort |
c–c bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/95853 http://hdl.handle.net/10220/11287 |
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1725985649199153152 |