C–C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature

Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good...

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Bibliographic Details
Main Authors: Isley, Nicholas A., Lipshutz, Bruce H., Huang, Shenlin, Leong, Wendy Wen Yi, Zhong, Guofu
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/95853
http://hdl.handle.net/10220/11287
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Institution: Nanyang Technological University
Language: English

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