Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles

Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles

A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading t...

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Main Authors: Toh, Kah Kah, Sanjaya, Stephen, Sahnoun, Sophian, Chong, Sin Yee, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/96081
http://hdl.handle.net/10220/10603
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-960812020-03-07T12:31:29Z Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles Toh, Kah Kah Sanjaya, Stephen Sahnoun, Sophian Chong, Sin Yee Chiba, Shunsuke School of Physical and Mathematical Sciences A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives. 2013-06-25T03:46:18Z 2019-12-06T19:25:19Z 2013-06-25T03:46:18Z 2019-12-06T19:25:19Z 2012 2012 Journal Article Toh, K. K., Sanjaya, S., Sahnoun, S., Chong, S. Y., & Chiba, S. (2012). Copper-Catalyzed Aerobic Intramolecular Carbo- and Amino-Oxygenation of Alkynes for Synthesis of Azaheterocycles. Organic Letters, 14(9), 2290-2292. 1523-7060 https://hdl.handle.net/10356/96081 http://hdl.handle.net/10220/10603 10.1021/ol3007106 en Organic letters © 2012 American Chemical Society.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Toh, Kah Kah
Sanjaya, Stephen
Sahnoun, Sophian
Chong, Sin Yee
Chiba, Shunsuke
format Article
author Toh, Kah Kah
Sanjaya, Stephen
Sahnoun, Sophian
Chong, Sin Yee
Chiba, Shunsuke
spellingShingle Toh, Kah Kah
Sanjaya, Stephen
Sahnoun, Sophian
Chong, Sin Yee
Chiba, Shunsuke
Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
author_sort Toh, Kah Kah
title Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
title_short Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
title_full Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
title_fullStr Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
title_full_unstemmed Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
title_sort copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles
publishDate 2013
url https://hdl.handle.net/10356/96081
http://hdl.handle.net/10220/10603
_version_ 1681042429629693952

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