Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation

• Main Authors: Low, Daren., Chen, Ken-Shiung.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/96280; http://hdl.handle.net/10220/7170
• Institution: Nanyang Technological University

Angelman syndrome (AS) is a human neurological disorder caused by lack of maternal UBE3A expression in the brain. Currently, the pathogenesis of AS, and how deficiency of maternal UBE3A can upset cellular homeostasis, remains vague. In this study, we performed a genomewide microarray analysis on the...