Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation

• المؤلفون الرئيسيون: Low, Daren., Chen, Ken-Shiung.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2011
• الموضوعات: DRNTU::Science::Biological sciences::Genetics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/96280; http://hdl.handle.net/10220/7170
• المؤسسة: Nanyang Technological University

Angelman syndrome (AS) is a human neurological disorder caused by lack of maternal UBE3A expression in the brain. Currently, the pathogenesis of AS, and how deficiency of maternal UBE3A can upset cellular homeostasis, remains vague. In this study, we performed a genomewide microarray analysis on the...