Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization
This Highlight Review describes a Cu–Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or α-arylvinyl azides with internal alkynes via C–H bond functionalization. A preliminary m...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2013
|
| Online Access: | https://hdl.handle.net/10356/96471 http://hdl.handle.net/10220/13037 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | This Highlight Review describes a Cu–Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or α-arylvinyl azides with internal alkynes via C–H bond functionalization. A preliminary mechanistic investigation revealed that both the Cu and Rh catalysts are prerequisites to achieve the present process, and play their particular roles with synergistic cooperation during the multistep sequence. |
|---|