Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization
This Highlight Review describes a Cu–Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or α-arylvinyl azides with internal alkynes via C–H bond functionalization. A preliminary m...
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sg-ntu-dr.10356-964712020-03-07T12:34:42Z Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization Chiba, Shunsuke School of Physical and Mathematical Sciences This Highlight Review describes a Cu–Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or α-arylvinyl azides with internal alkynes via C–H bond functionalization. A preliminary mechanistic investigation revealed that both the Cu and Rh catalysts are prerequisites to achieve the present process, and play their particular roles with synergistic cooperation during the multistep sequence. 2013-08-06T03:37:03Z 2019-12-06T19:31:12Z 2013-08-06T03:37:03Z 2019-12-06T19:31:12Z 2012 2012 Journal Article Chiba, S. (2012). Cu–Rh Redox Relay Catalysts for Synthesis of Azaheterocycles via C–H Functionalization. Chemistry Letters, 41(12), 1554-1559. https://hdl.handle.net/10356/96471 http://hdl.handle.net/10220/13037 10.1246/cl.2012.1554 en Chemistry letters |
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This Highlight Review describes a Cu–Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or α-arylvinyl azides with internal alkynes via C–H bond functionalization. A preliminary mechanistic investigation revealed that both the Cu and Rh catalysts are prerequisites to achieve the present process, and play their particular roles with synergistic cooperation during the multistep sequence. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Chiba, Shunsuke |
| format |
Article |
| author |
Chiba, Shunsuke |
| spellingShingle |
Chiba, Shunsuke Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| author_sort |
Chiba, Shunsuke |
| title |
Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| title_short |
Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| title_full |
Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| title_fullStr |
Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| title_full_unstemmed |
Cu–Rh redox relay catalysts for synthesis of azaheterocycles via C–H functionalization |
| title_sort |
cu–rh redox relay catalysts for synthesis of azaheterocycles via c–h functionalization |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/96471 http://hdl.handle.net/10220/13037 |
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1681036135974830080 |