Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic di-GMP signaling

• Main Authors: Rao, Feng., Chen, Ming Wei, Kotaka, Masayo, Vonrhein, Clemens, Bricogne, Gérard, Chuah, Mary Lay-Cheng, Svergun, Dmitri, Schneider, Gunter, Liang, Zhao-Xun, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96828; http://hdl.handle.net/10220/11651
• Institution: Nanyang Technological University

The nucleotide messenger cyclic di-GMP (c-di-GMP) plays a central role in the regulation of motility, virulence, and biofilm formation in many pathogenic bacteria. EAL domain-containing phosphodiesterases are the major signaling proteins responsible for the degradation of c-di-GMP and maintenance of...