Engineering of interlocked DNA G-quadruplexes as a robust scaffold

• Main Authors: Phan, Anh Tuân, Do, Ngoc Quang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/97175; http://hdl.handle.net/10220/9982
• Institution: Nanyang Technological University

Interlock is a structural element in DNA G-quadruplexes that can be compared with the commonly used complementary binding of ‘sticky ends’ in DNA duplexes. G-quadruplex interlocking can be a basis for the assembly of higher-order structures. In this study, we formulated a rule to engineer (3+1...