Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents p...

Full description

Saved in:
Bibliographic Details
Main Authors: Hammond, Paula T., Chan-Park, Mary B., Li, Peng, Rayatpisheh, Shahrzad, Zhou, Chuncai, Ye, Kai, Poon, Yin Fun, Duan, Hongwei
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97275
http://hdl.handle.net/10220/10456
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.

Similar Items