Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents p...

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Main Authors: Hammond, Paula T., Chan-Park, Mary B., Li, Peng, Rayatpisheh, Shahrzad, Zhou, Chuncai, Ye, Kai, Poon, Yin Fun, Duan, Hongwei
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97275
http://hdl.handle.net/10220/10456
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-972752020-03-07T11:35:37Z Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity Hammond, Paula T. Chan-Park, Mary B. Li, Peng Rayatpisheh, Shahrzad Zhou, Chuncai Ye, Kai Poon, Yin Fun Duan, Hongwei School of Chemical and Biomedical Engineering Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity. 2013-06-17T07:08:24Z 2019-12-06T19:40:49Z 2013-06-17T07:08:24Z 2019-12-06T19:40:49Z 2012 2012 Journal Article Li, P., Zhou, C., Rayatpisheh, S., Ye, K., Poon, Y. F., Hammond, P. T., et al. (2012). Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity. Advanced Materials, 24(30), 4130-4137. 1521-4095 https://hdl.handle.net/10356/97275 http://hdl.handle.net/10220/10456 10.1002/adma.201104186 en Advanced materials © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Hammond, Paula T.
Chan-Park, Mary B.
Li, Peng
Rayatpisheh, Shahrzad
Zhou, Chuncai
Ye, Kai
Poon, Yin Fun
Duan, Hongwei
format Article
author Hammond, Paula T.
Chan-Park, Mary B.
Li, Peng
Rayatpisheh, Shahrzad
Zhou, Chuncai
Ye, Kai
Poon, Yin Fun
Duan, Hongwei
spellingShingle Hammond, Paula T.
Chan-Park, Mary B.
Li, Peng
Rayatpisheh, Shahrzad
Zhou, Chuncai
Ye, Kai
Poon, Yin Fun
Duan, Hongwei
Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
author_sort Hammond, Paula T.
title Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
title_short Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
title_full Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
title_fullStr Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
title_full_unstemmed Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
title_sort cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity
publishDate 2013
url https://hdl.handle.net/10356/97275
http://hdl.handle.net/10220/10456
_version_ 1681045377668612096

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