Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts

Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts

The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

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Bibliographic Details
Main Authors: Hao, Lin, Du, Yu, Lv, Hui, Chen, Xingkuan, Jiang, Huishen, Shao, Yaling, Chi, Robin Yonggui
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97284
http://hdl.handle.net/10220/10637
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Institution: Nanyang Technological University
Language: English
Description
Summary:The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

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