Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts

• Main Authors: Hao, Lin, Du, Yu, Lv, Hui, Chen, Xingkuan, Jiang, Huishen, Shao, Yaling, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/97284; http://hdl.handle.net/10220/10637
• Institution: Nanyang Technological University

The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.