Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones

Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from...

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Main Authors: Wei, Ye, Deb, Indubhusan, Yoshikai, Naohiko
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/97583
http://hdl.handle.net/10220/11236
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-975832020-03-07T12:34:44Z Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones Wei, Ye Deb, Indubhusan Yoshikai, Naohiko School of Physical and Mathematical Sciences We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups. 2013-07-11T08:17:13Z 2019-12-06T19:44:18Z 2013-07-11T08:17:13Z 2019-12-06T19:44:18Z 2012 2012 Journal Article Wei, Y., Deb, I., & Yoshikai, N. (2012). Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones. Journal of the American Chemical Society, 134(22), 9098-9101. https://hdl.handle.net/10356/97583 http://hdl.handle.net/10220/11236 10.1021/ja3030824 en Journal of the American chemical society © 2012 American Chemical Society.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C–H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Wei, Ye
Deb, Indubhusan
Yoshikai, Naohiko
format Article
author Wei, Ye
Deb, Indubhusan
Yoshikai, Naohiko
spellingShingle Wei, Ye
Deb, Indubhusan
Yoshikai, Naohiko
Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
author_sort Wei, Ye
title Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
title_short Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
title_full Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
title_fullStr Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
title_full_unstemmed Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines : indole synthesis from anilines and ketones
title_sort palladium-catalyzed aerobic oxidative cyclization of n-aryl imines : indole synthesis from anilines and ketones
publishDate 2013
url https://hdl.handle.net/10356/97583
http://hdl.handle.net/10220/11236
_version_ 1681037313795162112

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