Membrane binding and insertion of a pHLIP peptide studied by all-atom molecular dynamics simulations

• Main Authors: Zhang, Yun, Deng, Yonghua, Qian, Zhenyu, Luo, Yin, Mu, Yuguang, Wei, Guanghong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/98126; http://hdl.handle.net/10220/12244
• Institution: Nanyang Technological University

Recent experiments in function mechanism study reported that a pH low-insertion peptide (pHLIP) can insert into a zwitterionic palmitoyloleoylphosphatidylcholine (POPC) lipid bilayer at acidic pH while binding to the bilayer surface at basic pH. However, the atomic details of the pH-dependent intera...