Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions
A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This me...
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sg-ntu-dr.10356-982742020-03-07T12:34:46Z Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions Yong, Fui-Fong. Teo, Yong-Chua. Chua, Guan-Leong. Yan, Yaw Kai. School of Physical and Mathematical Sciences A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides to afford products in good to excellent yields (up to 95%). 2013-07-26T06:14:04Z 2019-12-06T19:53:04Z 2013-07-26T06:14:04Z 2019-12-06T19:53:04Z 2012 2012 Journal Article Yong, F.-F., Teo, Y.-C., Yan, Y.-K., & Chua, G.-L. (2012). Low Catalyst Loadings for Copper-Catalyzed O-Arylation of Phenols with Aryl and Heteroaryl Halides under Mild Conditions. Synlett, 23, 101-106. https://hdl.handle.net/10356/98274 http://hdl.handle.net/10220/12381 10.1055/s-0031-1290110 en Synlett © 2012 Georg Thieme Verlag Stuttgart · New York. |
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A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This method tolerates a variety of functional groups including sterically hindered phenols and heteroaryl iodides to afford products in good to excellent yields (up to 95%). |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Yong, Fui-Fong. Teo, Yong-Chua. Chua, Guan-Leong. Yan, Yaw Kai. |
| format |
Article |
| author |
Yong, Fui-Fong. Teo, Yong-Chua. Chua, Guan-Leong. Yan, Yaw Kai. |
| spellingShingle |
Yong, Fui-Fong. Teo, Yong-Chua. Chua, Guan-Leong. Yan, Yaw Kai. Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| author_sort |
Yong, Fui-Fong. |
| title |
Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| title_short |
Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| title_full |
Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| title_fullStr |
Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| title_full_unstemmed |
Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| title_sort |
low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/98274 http://hdl.handle.net/10220/12381 |
| _version_ |
1681040139890982912 |