Low catalyst loadings for copper-catalyzed o-arylation of phenols with aryl and heteroaryl halides under mild conditions

• Main Authors: Yong, Fui-Fong., Teo, Yong-Chua., Chua, Guan-Leong., Yan, Yaw Kai.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/98274; http://hdl.handle.net/10220/12381
• Institution: Nanyang Technological University

A practical and mild strategy has been developed for the cross-coupling of O-arylation of phenol with differently substituted aryl halides and heteroaryl iodides using low catalyst loading of copper iodide under low operating temperature in DMF with TMHD as the ligand and Cs2CO3 as the base. This me...