Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activ...
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sg-ntu-dr.10356-982832020-03-07T12:34:46Z Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi School of Physical and Mathematical Sciences 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%). 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2012 2012 Journal Article Ilies, L., Kobayashi, M., Matsumoto, A., Yoshikai, N., & Nakamura, E. (2012). Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Advanced Synthesis & Catalysis, 354(4), 593-596. 1615-4150 https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 10.1002/adsc.201100791 en Advanced synthesis & catalysis © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%). |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi |
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Article |
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Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi |
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Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
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Ilies, Laurean |
title |
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
title_short |
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
title_full |
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
title_fullStr |
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
title_full_unstemmed |
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
title_sort |
iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
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2013 |
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https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 |
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