Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium

2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activ...

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Main Authors: Ilies, Laurean, Kobayashi, Motoaki, Matsumoto, Arimasa, Yoshikai, Naohiko, Nakamura, Eiichi
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/98283
http://hdl.handle.net/10220/12334
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-982832020-03-07T12:34:46Z Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi School of Physical and Mathematical Sciences 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%). 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2012 2012 Journal Article Ilies, L., Kobayashi, M., Matsumoto, A., Yoshikai, N., & Nakamura, E. (2012). Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Advanced Synthesis & Catalysis, 354(4), 593-596. 1615-4150 https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 10.1002/adsc.201100791 en Advanced synthesis & catalysis © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%).
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Ilies, Laurean
Kobayashi, Motoaki
Matsumoto, Arimasa
Yoshikai, Naohiko
Nakamura, Eiichi
format Article
author Ilies, Laurean
Kobayashi, Motoaki
Matsumoto, Arimasa
Yoshikai, Naohiko
Nakamura, Eiichi
spellingShingle Ilies, Laurean
Kobayashi, Motoaki
Matsumoto, Arimasa
Yoshikai, Naohiko
Nakamura, Eiichi
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
author_sort Ilies, Laurean
title Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
title_short Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
title_full Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
title_fullStr Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
title_full_unstemmed Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
title_sort iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
publishDate 2013
url https://hdl.handle.net/10356/98283
http://hdl.handle.net/10220/12334
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