Study on the oiling-out and crystallization for the purification of idebenone

• Main Authors: Lu, Jie, Li, Yi-Ping, Wang, Jing, Li, Zhen, Rohani, Sohrab, Ching, Chi Bun
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Chemical engineering::Chemical processes
• Online Access: https://hdl.handle.net/10356/99038; http://hdl.handle.net/10220/17124
• Institution: Nanyang Technological University

Oiling-out, also termed as demixing or liquid–liquid phase separation (LLPS), frequently occurs in the crystallization process of pharmaceuticals and normally results in slow crystal growth, uncontrollable crystal morphology, and low purity of products. In this work, the oiling-out and cooling cryst...