Study on the oiling-out and crystallization for the purification of idebenone

• Main Authors: Lu, Jie, Li, Yi-Ping, Wang, Jing, Li, Zhen, Rohani, Sohrab, Ching, Chi Bun
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2013
• 主題: DRNTU::Engineering::Chemical engineering::Chemical processes
• 在線閱讀: https://hdl.handle.net/10356/99038; http://hdl.handle.net/10220/17124
• 機構: Nanyang Technological University

Oiling-out, also termed as demixing or liquid–liquid phase separation (LLPS), frequently occurs in the crystallization process of pharmaceuticals and normally results in slow crystal growth, uncontrollable crystal morphology, and low purity of products. In this work, the oiling-out and cooling cryst...