Study on the oiling-out and crystallization for the purification of idebenone

• المؤلفون الرئيسيون: Lu, Jie, Li, Yi-Ping, Wang, Jing, Li, Zhen, Rohani, Sohrab, Ching, Chi Bun
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Engineering::Chemical engineering::Chemical processes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99038; http://hdl.handle.net/10220/17124
• المؤسسة: Nanyang Technological University

Oiling-out, also termed as demixing or liquid–liquid phase separation (LLPS), frequently occurs in the crystallization process of pharmaceuticals and normally results in slow crystal growth, uncontrollable crystal morphology, and low purity of products. In this work, the oiling-out and cooling cryst...