ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain

• Main Authors: Chia, Wei Sheng, Chia, Diana Xueqi, Rao, Feng, Nun, Shoshana Bar, Shochat, Susana Geifman
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/99093; http://hdl.handle.net/10220/10921
• Institution: Nanyang Technological University

p97/Valosin-containing protein (VCP) is a member of the AAA-ATPase family involved in many cellular processes including cell division, intracellular trafficking and extraction of misfolded proteins in endoplasmic reticulum-associated degradation (ERAD). It is a homohexamer with each subunit containi...