A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.

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Bibliographic Details
Main Authors: Chen, Ke, Pullarkat, Sumod A.
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/99176
http://hdl.handle.net/10220/17155
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Institution: Nanyang Technological University
Language: English