A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

• Main Authors: Chen, Ke, Pullarkat, Sumod A.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/99176; http://hdl.handle.net/10220/17155
• Institution: Nanyang Technological University

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.