Domino cyclization–alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols

• Main Authors: Xu, Chang., Murugan, Vinod K., Pullarkat, Sumod A.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/99216; http://hdl.handle.net/10220/17156
• Institution: Nanyang Technological University

A practical and efficient protocol for the one-pot synthesis of 2,3-substituted indoles was developed via a palladacycle catalyzed domino cyclization–alkylation reaction involving 2-alkynylanilines and allylic alcohols under mild conditions without any additives.