Structures of Aβ17–42 trimers in isolation and with five small-molecule drugs using a hierarchical computational procedure
The amyloid-β protein (Aβ) oligomers are believed to be the main culprits in the cytoxicity of Alzheimer’s disease (AD) and p3 peptides (Aβ17–42 fragments) are present in AD amyloid plaques. Many small-molecule or peptide-based inhibitors are known to slow down Aβ aggregation and reduce the toxicity...
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| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/99781 http://hdl.handle.net/10220/17181 |
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| Institution: | Nanyang Technological University |
| Language: | English |