Cd8+ T cells and IFN-? mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria

• Main Authors: Claser C., Malleret B., Gun S.Y., Wong A.Y.W., Chang Z.W., Teo P., See P.C.E., Howland S.W., Ginhoux F., Rénia L.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: gamma interferon; interleukin 12; luciferase; tumor necrosis factor alpha; DNA binding protein; Rag2 protein, mouse; animal cell; animal experiment; animal model; animal tissue; article; bioaccumulation; brain malaria; CD4+ T lymphocyte; CD8+ T lymphocyte; cell selection; cell subpopulation; cellular distribution; diagnostic imaging; disease course; erythrocyte; ex vivo study; female; in vivo study; male; microbial biomass; monocyte; mouse; neutrophil; nonhuman; organ; pathogenesis; Plasmodium berghei; Plasmodium berghei infection; protein expression; time lapse imaging; animal; antibody specificity; biomass; bone marrow cell; brain; C57BL mouse; immunology; lymphocyte depletion; malaria; metabolism; parasitology; pathology; physiology; time; Mus; Animals; Biomass; Brain; CD8-Positive T-Lymphocytes; DNA-Binding Proteins; Erythrocytes; Female; Interferon-gamma; Lymphocyte Depletion; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Myeloid Cells; Organ Specificity; Time Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161795
• Institution: National University of Singapore

10.1371/journal.pone.0018720