The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication
10.1371/journal.pntd.0002891
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sg-nus-scholar.10635-1619512023-09-21T08:25:18Z The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication Li X.-D. Shan C. Deng C.-L. Ye H.-Q. Shi P.-Y. Yuan Z.-M. Gong P. Zhang B. DUKE-NUS MEDICAL SCHOOL complementary DNA methyltransferase nonstructural protein 5 RNA directed RNA polymerase virus RNA DNA directed RNA polymerase methyltransferase NS5 protein, flavivirus virus protein animal cell article controlled study electroporation enzyme activity Flavivirus infection gene mutation gene sequence genetic transfection immunofluorescence microscopy immunofluorescence test Japanese encephalitis virus luciferase assay molecular interaction nonhuman replicon reverse transcription polymerase chain reaction RNA extraction RNA replication RNA transcription virus genome virus mutant virus plaque virus replication amino acid sequence cell line chemical phenomena chemistry Flavivirus genetics molecular genetics nucleotide sequence physiology sequence alignment virus replication Amino Acid Sequence Cell Line Conserved Sequence DNA-Directed RNA Polymerases Flavivirus Hydrophobic and Hydrophilic Interactions Methyltransferases Molecular Sequence Data Sequence Alignment Viral Nonstructural Proteins Virus Replication 10.1371/journal.pntd.0002891 PLoS Neglected Tropical Diseases 8 5 e2891 2019-11-08T08:50:28Z 2019-11-08T08:50:28Z 2014 Article Li X.-D., Shan C., Deng C.-L., Ye H.-Q., Shi P.-Y., Yuan Z.-M., Gong P., Zhang B. (2014). The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication. PLoS Neglected Tropical Diseases 8 (5) : e2891. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002891 19352727 https://scholarbank.nus.edu.sg/handle/10635/161951 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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complementary DNA methyltransferase nonstructural protein 5 RNA directed RNA polymerase virus RNA DNA directed RNA polymerase methyltransferase NS5 protein, flavivirus virus protein animal cell article controlled study electroporation enzyme activity Flavivirus infection gene mutation gene sequence genetic transfection immunofluorescence microscopy immunofluorescence test Japanese encephalitis virus luciferase assay molecular interaction nonhuman replicon reverse transcription polymerase chain reaction RNA extraction RNA replication RNA transcription virus genome virus mutant virus plaque virus replication amino acid sequence cell line chemical phenomena chemistry Flavivirus genetics molecular genetics nucleotide sequence physiology sequence alignment virus replication Amino Acid Sequence Cell Line Conserved Sequence DNA-Directed RNA Polymerases Flavivirus Hydrophobic and Hydrophilic Interactions Methyltransferases Molecular Sequence Data Sequence Alignment Viral Nonstructural Proteins Virus Replication |
| spellingShingle |
complementary DNA methyltransferase nonstructural protein 5 RNA directed RNA polymerase virus RNA DNA directed RNA polymerase methyltransferase NS5 protein, flavivirus virus protein animal cell article controlled study electroporation enzyme activity Flavivirus infection gene mutation gene sequence genetic transfection immunofluorescence microscopy immunofluorescence test Japanese encephalitis virus luciferase assay molecular interaction nonhuman replicon reverse transcription polymerase chain reaction RNA extraction RNA replication RNA transcription virus genome virus mutant virus plaque virus replication amino acid sequence cell line chemical phenomena chemistry Flavivirus genetics molecular genetics nucleotide sequence physiology sequence alignment virus replication Amino Acid Sequence Cell Line Conserved Sequence DNA-Directed RNA Polymerases Flavivirus Hydrophobic and Hydrophilic Interactions Methyltransferases Molecular Sequence Data Sequence Alignment Viral Nonstructural Proteins Virus Replication Li X.-D. Shan C. Deng C.-L. Ye H.-Q. Shi P.-Y. Yuan Z.-M. Gong P. Zhang B. The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| description |
10.1371/journal.pntd.0002891 |
| author2 |
DUKE-NUS MEDICAL SCHOOL |
| author_facet |
DUKE-NUS MEDICAL SCHOOL Li X.-D. Shan C. Deng C.-L. Ye H.-Q. Shi P.-Y. Yuan Z.-M. Gong P. Zhang B. |
| format |
Article |
| author |
Li X.-D. Shan C. Deng C.-L. Ye H.-Q. Shi P.-Y. Yuan Z.-M. Gong P. Zhang B. |
| author_sort |
Li X.-D. |
| title |
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| title_short |
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| title_full |
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| title_fullStr |
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| title_full_unstemmed |
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication |
| title_sort |
interface between methyltransferase and polymerase of ns5 is essential for flavivirus replication |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/161951 |
| _version_ |
1778169228954697728 |