The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes

• Main Authors: Renga B., Francisci D., D'Amore C., Schiaroli E., Mencarelli A., Cipriani S., Baldelli F., Fiorucci S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: CD36 antigen; CD40 antigen; CD86 antigen; cell nucleus receptor; farnesoid X receptor; intercellular adhesion molecule 1; Janus kinase 1; monocyte chemotactic protein 1; peptide vaccine; peroxisome proliferator activated receptor gamma; protein p17; receptor for activated C kinase 1; recombinant protein; STAT1 protein; 2,4 thiazolidinedione derivative; 3 [2 [2 chloro 4 [3 (2,6 dichlorophenyl) 5 isopropyl 4 isoxazolylmethoxy]phenyl]vinyl]benzoic acid; CD14 antigen; cell receptor; cell surface receptor; drug derivative; farnesoid X-activated receptor; fludarabine; Gag protein; GNB2L1 protein, human; guanine nucleotide binding protein; Human immunodeficiency virus antigen; isoxazole derivative; Janus kinase; p17 protein, Human Immunodeficiency Virus Type 1; rosiglitazone; STAT1 protein, human; tumor protein; vidarabine; article; controlled study; down regulation; gene control; gene expression; human; human cell; Human immunodeficiency virus 1; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; inflammation; lipid metabolism; macrophage; monocyte; promoter region; protein expression; signal transduction; vaccination; atherosclerosis; cell line; cell separation; drug effect; drug potentiation; enzymology; gene expression regulation; genetics; immunology; metabolism; pathology; phenotype; phosphorylation; serodiagnosis; Antigens, CD14; Atherosclerosis; Cell Line; Cell Separation; gag Gene Products, Human Immunodeficiency Virus; Gene Expression Regulation; GTP-Binding Proteins; HIV Antigens; HIV Infections; HIV-1; Humans; Inflammation; Isoxazoles; Janus Kinases; Lipid Metabolism; Macrophages; Monocytes; Neoplasm Proteins; Neutralization Tests; Phenotype; Phosphorylation; PPAR gamma; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Signal Transduction; STAT1 Transcription Factor; Thiazolidinediones; Vaccination; Vidarabine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161986
• Institution: National University of Singapore

10.1371/journal.pone.0035924