The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

10.1371/journal.pone.0025637

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Main Authors: Cipriani S., Mencarelli A., Chini M.G., Distrutti E., Renga B., Bifulco G., Baldelli F., Donini A., Fiorucci S.
Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Format: Article
Published: 2019
Subjects:
Mus
Online Access:https://scholarbank.nus.edu.sg/handle/10635/162026
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spelling sg-nus-scholar.10635-1620262021-02-19T09:39:03Z The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis Cipriani S. Mencarelli A. Chini M.G. Distrutti E. Renga B. Bifulco G. Baldelli F. Donini A. Fiorucci S. DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) DUKE-NUS MEDICAL SCHOOL CD14 antigen ciprofloxacin cyclic AMP gap junction protein oleanolic acid toll like receptor 4 trinitrobenzenesulfonic acid tumor necrosis factor alpha unclassified drug zonulin 1 cholera toxin ciprofloxacin G protein coupled receptor Gpbar1 protein, mouse ligand zonulin adult animal cell animal experiment animal model animal tissue antiinflammatory activity article cell isolation cell junction cell structure cellular distribution colitis controlled study Crohn disease disease severity dose response drug dose comparison drug mechanism drug structure female flow cytometry G protein coupled bile acid receptor 1 gene gene deletion gene expression regulation gene function homeostasis human human tissue immune response immunomodulation immunoregulation intestine mucosa permeability male molecular docking mucous cell nonhuman receptor gene screening test wild type animal chemically induced disorder colitis immunity immunology intestine mucosa mouse mouse mutant pathology permeability physiology tight junction Mus Rodentia Animals Cholera Toxin Ciprofloxacin Colitis Immunity Intestinal Mucosa Ligands Mice Mice, Knockout Permeability Receptors, G-Protein-Coupled Tight Junctions 10.1371/journal.pone.0025637 PLoS ONE 6 10 e25637 2019-11-11T08:36:54Z 2019-11-11T08:36:54Z 2011 Article Cipriani S., Mencarelli A., Chini M.G., Distrutti E., Renga B., Bifulco G., Baldelli F., Donini A., Fiorucci S. (2011). The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 6 (10) : e25637. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0025637 19326203 https://scholarbank.nus.edu.sg/handle/10635/162026 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic CD14 antigen
ciprofloxacin
cyclic AMP
gap junction protein
oleanolic acid
toll like receptor 4
trinitrobenzenesulfonic acid
tumor necrosis factor alpha
unclassified drug
zonulin 1
cholera toxin
ciprofloxacin
G protein coupled receptor
Gpbar1 protein, mouse
ligand
zonulin
adult
animal cell
animal experiment
animal model
animal tissue
antiinflammatory activity
article
cell isolation
cell junction
cell structure
cellular distribution
colitis
controlled study
Crohn disease
disease severity
dose response
drug dose comparison
drug mechanism
drug structure
female
flow cytometry
G protein coupled bile acid receptor 1 gene
gene deletion
gene expression regulation
gene function
homeostasis
human
human tissue
immune response
immunomodulation
immunoregulation
intestine mucosa permeability
male
molecular docking
mucous cell
nonhuman
receptor gene
screening test
wild type
animal
chemically induced disorder
colitis
immunity
immunology
intestine mucosa
mouse
mouse mutant
pathology
permeability
physiology
tight junction
Mus
Rodentia
Animals
Cholera Toxin
Ciprofloxacin
Colitis
Immunity
Intestinal Mucosa
Ligands
Mice
Mice, Knockout
Permeability
Receptors, G-Protein-Coupled
Tight Junctions
spellingShingle CD14 antigen
ciprofloxacin
cyclic AMP
gap junction protein
oleanolic acid
toll like receptor 4
trinitrobenzenesulfonic acid
tumor necrosis factor alpha
unclassified drug
zonulin 1
cholera toxin
ciprofloxacin
G protein coupled receptor
Gpbar1 protein, mouse
ligand
zonulin
adult
animal cell
animal experiment
animal model
animal tissue
antiinflammatory activity
article
cell isolation
cell junction
cell structure
cellular distribution
colitis
controlled study
Crohn disease
disease severity
dose response
drug dose comparison
drug mechanism
drug structure
female
flow cytometry
G protein coupled bile acid receptor 1 gene
gene deletion
gene expression regulation
gene function
homeostasis
human
human tissue
immune response
immunomodulation
immunoregulation
intestine mucosa permeability
male
molecular docking
mucous cell
nonhuman
receptor gene
screening test
wild type
animal
chemically induced disorder
colitis
immunity
immunology
intestine mucosa
mouse
mouse mutant
pathology
permeability
physiology
tight junction
Mus
Rodentia
Animals
Cholera Toxin
Ciprofloxacin
Colitis
Immunity
Intestinal Mucosa
Ligands
Mice
Mice, Knockout
Permeability
Receptors, G-Protein-Coupled
Tight Junctions
Cipriani S.
Mencarelli A.
Chini M.G.
Distrutti E.
Renga B.
Bifulco G.
Baldelli F.
Donini A.
Fiorucci S.
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
description 10.1371/journal.pone.0025637
author2 DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
author_facet DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
Cipriani S.
Mencarelli A.
Chini M.G.
Distrutti E.
Renga B.
Bifulco G.
Baldelli F.
Donini A.
Fiorucci S.
format Article
author Cipriani S.
Mencarelli A.
Chini M.G.
Distrutti E.
Renga B.
Bifulco G.
Baldelli F.
Donini A.
Fiorucci S.
author_sort Cipriani S.
title The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
title_short The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
title_full The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
title_fullStr The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
title_full_unstemmed The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
title_sort bile acid receptor gpbar-1 (tgr5) modulates integrity of intestinal barrier and immune response to experimental colitis
publishDate 2019
url https://scholarbank.nus.edu.sg/handle/10635/162026
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