The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis

• Main Authors: Cipriani S., Mencarelli A., Chini M.G., Distrutti E., Renga B., Bifulco G., Baldelli F., Donini A., Fiorucci S.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: CD14 antigen; ciprofloxacin; cyclic AMP; gap junction protein; oleanolic acid; toll like receptor 4; trinitrobenzenesulfonic acid; tumor necrosis factor alpha; unclassified drug; zonulin 1; cholera toxin; G protein coupled receptor; Gpbar1 protein, mouse; ligand; zonulin; adult; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; article; cell isolation; cell junction; cell structure; cellular distribution; colitis; controlled study; Crohn disease; disease severity; dose response; drug dose comparison; drug mechanism; drug structure; female; flow cytometry; G protein coupled bile acid receptor 1 gene; gene deletion; gene expression regulation; gene function; homeostasis; human; human tissue; immune response; immunomodulation; immunoregulation; intestine mucosa permeability; male; molecular docking; mucous cell; nonhuman; receptor gene; screening test; wild type; animal; chemically induced disorder; immunity; immunology; intestine mucosa; mouse; mouse mutant; pathology; permeability; physiology; tight junction; Mus; Rodentia; Animals; Cholera Toxin; Ciprofloxacin; Colitis; Immunity; Intestinal Mucosa; Ligands; Mice; Mice, Knockout; Permeability; Receptors, G-Protein-Coupled; Tight Junctions
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162026
• Institution: National University of Singapore

10.1371/journal.pone.0025637