Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

• Main Authors: Schmidt K.E., Kuepper J.M., Schumak B., Alferink J., Hofmann A., Howland S.W., Rénia L., Limmer A., Specht S., Hoerauf A.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: chemokine; doxycycline; gamma interferon; gelatinase A; granzyme B; interleukin 10; tumor necrosis factor; antimalarial agent; autacoid; gelatinase B; IL10 protein, mouse; Mmp2 protein, mouse; Mmp9 protein, mouse; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; CD8+ T lymphocyte; cell isolation; cerebral malaria; controlled study; cytotoxicity; disease course; encephalitis; enzyme linked immunosorbent assay; female; immunity; in vivo study; lymphocytic infiltration; mouse; nonhuman; parasite load; parasitemia; pathology; Plasmodium berghei; protein expression; real time polymerase chain reaction; RNA isolation; spleen cell; T lymphocyte; tissue degeneration; zymography; animal; C57BL mouse; disease model; drug effects; immunology; inflammation; lymphocyte activation; metabolism; parasitology; pathogenicity; spleen; T lymphocyte subpopulation; Animals; Antimalarials; Blood-Brain Barrier; Chemokines; Disease Models, Animal; Doxycycline; Female; Inflammation; Inflammation Mediators; Interleukin-10; Lymphocyte Activation; Malaria, Cerebral; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Parasitemia; Spleen; T-Lymphocyte Subsets
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165969
• Institution: National University of Singapore

10.1371/journal.pone.0192717