Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

10.1371/journal.pone.0192717

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Main Authors:	Schmidt K.E., Kuepper J.M., Schumak B., Alferink J., Hofmann A., Howland S.W., Rénia L., Limmer A., Specht S., Hoerauf A.
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Published:	Public Library of Science 2020
Subjects:	chemokine doxycycline gamma interferon gelatinase A granzyme B interleukin 10 tumor necrosis factor antimalarial agent autacoid gelatinase B IL10 protein, mouse Mmp2 protein, mouse Mmp9 protein, mouse animal cell animal experiment animal model animal tissue Article blood brain barrier CD8+ T lymphocyte cell isolation cerebral malaria controlled study cytotoxicity disease course encephalitis enzyme linked immunosorbent assay female immunity in vivo study lymphocytic infiltration mouse nonhuman parasite load parasitemia pathology Plasmodium berghei protein expression real time polymerase chain reaction RNA isolation spleen cell T lymphocyte tissue degeneration zymography animal C57BL mouse disease model drug effects immunology inflammation lymphocyte activation metabolism parasitology pathogenicity spleen T lymphocyte subpopulation Animals Antimalarials Blood-Brain Barrier Chemokines Disease Models, Animal Doxycycline Female Inflammation Inflammation Mediators Interleukin-10 Lymphocyte Activation Malaria, Cerebral Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Mice Mice, Inbred C57BL Parasitemia Spleen T-Lymphocyte Subsets
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/165969
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1659692024-03-27T08:20:24Z Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators Schmidt K.E. Kuepper J.M. Schumak B. Alferink J. Hofmann A. Howland S.W. Rénia L. Limmer A. Specht S. Hoerauf A. MICROBIOLOGY AND IMMUNOLOGY chemokine doxycycline gamma interferon gelatinase A granzyme B interleukin 10 tumor necrosis factor antimalarial agent autacoid chemokine doxycycline gelatinase A gelatinase B IL10 protein, mouse interleukin 10 Mmp2 protein, mouse Mmp9 protein, mouse animal cell animal experiment animal model animal tissue Article blood brain barrier CD8+ T lymphocyte cell isolation cerebral malaria controlled study cytotoxicity disease course encephalitis enzyme linked immunosorbent assay female immunity in vivo study lymphocytic infiltration mouse nonhuman parasite load parasitemia pathology Plasmodium berghei protein expression real time polymerase chain reaction RNA isolation spleen cell T lymphocyte tissue degeneration zymography animal C57BL mouse cerebral malaria disease model drug effects immunology inflammation lymphocyte activation metabolism parasitemia parasitology pathogenicity spleen T lymphocyte subpopulation Animals Antimalarials Blood-Brain Barrier Chemokines Disease Models, Animal Doxycycline Female Inflammation Inflammation Mediators Interleukin-10 Lymphocyte Activation Malaria, Cerebral Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Mice Mice, Inbred C57BL Parasitemia Plasmodium berghei Spleen T-Lymphocyte Subsets 10.1371/journal.pone.0192717 PLoS ONE 13 2 e0192717 2020-03-27T01:05:28Z 2020-03-27T01:05:28Z 2018 Article Schmidt K.E., Kuepper J.M., Schumak B., Alferink J., Hofmann A., Howland S.W., Rénia L., Limmer A., Specht S., Hoerauf A. (2018). Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators. PLoS ONE 13 (2) : e0192717. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0192717 19326203 https://scholarbank.nus.edu.sg/handle/10635/165969 Public Library of Science Unpaywall 20200320
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	chemokine doxycycline gamma interferon gelatinase A granzyme B interleukin 10 tumor necrosis factor antimalarial agent autacoid chemokine doxycycline gelatinase A gelatinase B IL10 protein, mouse interleukin 10 Mmp2 protein, mouse Mmp9 protein, mouse animal cell animal experiment animal model animal tissue Article blood brain barrier CD8+ T lymphocyte cell isolation cerebral malaria controlled study cytotoxicity disease course encephalitis enzyme linked immunosorbent assay female immunity in vivo study lymphocytic infiltration mouse nonhuman parasite load parasitemia pathology Plasmodium berghei protein expression real time polymerase chain reaction RNA isolation spleen cell T lymphocyte tissue degeneration zymography animal C57BL mouse cerebral malaria disease model drug effects immunology inflammation lymphocyte activation metabolism parasitemia parasitology pathogenicity spleen T lymphocyte subpopulation Animals Antimalarials Blood-Brain Barrier Chemokines Disease Models, Animal Doxycycline Female Inflammation Inflammation Mediators Interleukin-10 Lymphocyte Activation Malaria, Cerebral Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Mice Mice, Inbred C57BL Parasitemia Plasmodium berghei Spleen T-Lymphocyte Subsets
spellingShingle	chemokine doxycycline gamma interferon gelatinase A granzyme B interleukin 10 tumor necrosis factor antimalarial agent autacoid chemokine doxycycline gelatinase A gelatinase B IL10 protein, mouse interleukin 10 Mmp2 protein, mouse Mmp9 protein, mouse animal cell animal experiment animal model animal tissue Article blood brain barrier CD8+ T lymphocyte cell isolation cerebral malaria controlled study cytotoxicity disease course encephalitis enzyme linked immunosorbent assay female immunity in vivo study lymphocytic infiltration mouse nonhuman parasite load parasitemia pathology Plasmodium berghei protein expression real time polymerase chain reaction RNA isolation spleen cell T lymphocyte tissue degeneration zymography animal C57BL mouse cerebral malaria disease model drug effects immunology inflammation lymphocyte activation metabolism parasitemia parasitology pathogenicity spleen T lymphocyte subpopulation Animals Antimalarials Blood-Brain Barrier Chemokines Disease Models, Animal Doxycycline Female Inflammation Inflammation Mediators Interleukin-10 Lymphocyte Activation Malaria, Cerebral Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Mice Mice, Inbred C57BL Parasitemia Plasmodium berghei Spleen T-Lymphocyte Subsets Schmidt K.E. Kuepper J.M. Schumak B. Alferink J. Hofmann A. Howland S.W. Rénia L. Limmer A. Specht S. Hoerauf A. Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
description	10.1371/journal.pone.0192717
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Schmidt K.E. Kuepper J.M. Schumak B. Alferink J. Hofmann A. Howland S.W. Rénia L. Limmer A. Specht S. Hoerauf A.
format	Article
author	Schmidt K.E. Kuepper J.M. Schumak B. Alferink J. Hofmann A. Howland S.W. Rénia L. Limmer A. Specht S. Hoerauf A.
author_sort	Schmidt K.E.
title	Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
title_short	Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
title_full	Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
title_fullStr	Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
title_full_unstemmed	Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
title_sort	doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators
publisher	Public Library of Science
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/165969
_version_	1795300833276985344

Doxycycline inhibits experimental cerebral malaria by reducing inflammatory immune reactions and tissue-degrading mediators

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