Characterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans

• Main Authors: Lee I.R., Yang L., Sebetso G., Allen R., Doan T.H.N., Blundell R., Lui E.Y.L., Morrow C.A., Fraser J.A.
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: uric acid; animal experiment; animal model; article; controlled study; Cryptococcus neoformans; DAL1 gene; DAL2 3 3 gene; female; fungal gene; fungal metabolism; fungal virulence; gene function; gene identification; mouse; nonhuman; open reading frame; purine metabolism; recombination repair; URE1 gene; URO1 gene; URO2 gene; URO3 gene; Agrobacterium; Animals; Caenorhabditis elegans; Computational Biology; Cryptococcosis; Fungal Capsules; Fungal Proteins; Gene Deletion; Host-Pathogen Interactions; Humans; Hydrolases; Melanins; Metabolic Networks and Pathways; Mice; Mutagenesis, Insertional; Nitrogen; Phenotype; Purines; Reproducibility of Results; Reproduction; Reverse Genetics; Temperature; Urease; Uric Acid
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/166575
• Institution: National University of Singapore

10.1371/journal.pone.0064292