Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity

• Main Authors: Chan, James Chun Yip, Soh, Alex Cheow Khoon, Kioh, Dorinda Yan Qin, Li, Jianguo, Verma, Chandra, Koh, Siew Kwan, Beuerman, Roger Wilmer, Zhou, Lei, Chan, Eric Chun Yong
• Other Authors: BIOLOGY (NU)
• Format: Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology Inc. 2020
• Subjects: Science & Technology; Life Sciences & Biomedicine; Biochemical Research Methods; Biochemistry & Molecular Biology; Post-translational modifications; Metabolomics; Chemical biology; Protein Modification; Protein adducts; Acetaminophen; Drug-induced toxicity; Hepatotoxicity; Protein glutathionylation; PARA-BENZOQUINONE IMINE; S-GLUTATHIONYLATION; IN-VIVO; MITOCHONDRIAL RESPIRATION; COVALENT BINDING; OXIDATIVE STRESS; REDOX REGULATION; PLASMA-MEMBRANE; OXIDANT STRESS; LIVER
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/171313
• Institution: National University of Singapore

10.1074/mcp.RA118.000875