Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish

• Main Authors: Yan, C, Yang, Q, Shen, H.-M, Spitsbergen, J.M, Gong, Z
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2020
• Subjects: leptin; mitogen activated protein kinase; Smad protein; transforming growth factor beta1; adult; animal cell; animal experiment; animal model; animal tissue; Article; bile duct carcinoma; carcinogenesis; carcinogenicity; cholangiocyte; controlled study; disease course; gene induction; gene overexpression; hormone response; human; human tissue; larva; liver cell; liver cell carcinoma; long term exposure; MAPK signaling; molecular pathology; nonalcoholic fatty liver; nonhuman; oncogene; protein expression; satiety; tgfb1a gene; transgenic zebrafish
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173801
• Institution: National University of Singapore

10.18632/oncotarget.20357