A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

10.18632/oncotarget.14606

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Bibliographic Details
Main Authors:	Dai X., Wang L., Deivasigamni A., Looi C.Y., Karthikeyan C., Trivedi P., Chinnathambi A., Alharbi S.A., Arfuso F., Dharmarajan A., Goh B.C., Hui K.M., Kumar A.P., Mustafa M.R., Sethi G.
Other Authors:	PHARMACY
Format:	Article
Published:	2020
Subjects:	acetylcysteine benzimidazole derivative caspase 3 methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate reactive oxygen metabolite stress activated protein kinase unclassified drug animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell invasion cell migration cell viability controlled study female flow cytometry human human cell liver cell carcinoma mitochondrion mouse nonhuman signal transduction Western blotting
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173807
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Institution:	National University of Singapore

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Summary:	10.18632/oncotarget.14606