A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

• Main Authors: Dai X., Wang L., Deivasigamni A., Looi C.Y., Karthikeyan C., Trivedi P., Chinnathambi A., Alharbi S.A., Arfuso F., Dharmarajan A., Goh B.C., Hui K.M., Kumar A.P., Mustafa M.R., Sethi G.
• Other Authors: PHARMACY
• Format: Article
• Published: 2020
• Subjects: acetylcysteine; benzimidazole derivative; caspase 3; methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate; reactive oxygen metabolite; stress activated protein kinase; unclassified drug; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; cancer inhibition; cell invasion; cell migration; cell viability; controlled study; female; flow cytometry; human; human cell; liver cell carcinoma; mitochondrion; mouse; nonhuman; signal transduction; Western blotting
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173807
• Institution: National University of Singapore

10.18632/oncotarget.14606