A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

10.18632/oncotarget.14606

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Main Authors:	Dai X., Wang L., Deivasigamni A., Looi C.Y., Karthikeyan C., Trivedi P., Chinnathambi A., Alharbi S.A., Arfuso F., Dharmarajan A., Goh B.C., Hui K.M., Kumar A.P., Mustafa M.R., Sethi G.
Other Authors:	PHARMACY
Format:	Article
Published:	2020
Subjects:	acetylcysteine benzimidazole derivative caspase 3 methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate reactive oxygen metabolite stress activated protein kinase unclassified drug animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell invasion cell migration cell viability controlled study female flow cytometry human human cell liver cell carcinoma mitochondrion mouse nonhuman signal transduction Western blotting
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/173807
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1738072024-04-05T09:03:34Z A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma Dai X. Wang L. Deivasigamni A. Looi C.Y. Karthikeyan C. Trivedi P. Chinnathambi A. Alharbi S.A. Arfuso F. Dharmarajan A. Goh B.C. Hui K.M. Kumar A.P. Mustafa M.R. Sethi G. PHARMACY PHARMACOLOGY DUKE-NUS MEDICAL SCHOOL CANCER SCIENCE INSTITUTE OF SINGAPORE acetylcysteine benzimidazole derivative caspase 3 methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate reactive oxygen metabolite stress activated protein kinase unclassified drug animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell invasion cell migration cell viability controlled study female flow cytometry human human cell liver cell carcinoma mitochondrion mouse nonhuman signal transduction Western blotting 10.18632/oncotarget.14606 Oncotarget 8 8 12831-12842 2020-09-01T00:59:03Z 2020-09-01T00:59:03Z 2017 Article Dai X., Wang L., Deivasigamni A., Looi C.Y., Karthikeyan C., Trivedi P., Chinnathambi A., Alharbi S.A., Arfuso F., Dharmarajan A., Goh B.C., Hui K.M., Kumar A.P., Mustafa M.R., Sethi G. (2017). A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget 8 (8) : 12831-12842. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.14606 19492553 https://scholarbank.nus.edu.sg/handle/10635/173807 Unpaywall 20200831
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	acetylcysteine benzimidazole derivative caspase 3 methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate reactive oxygen metabolite stress activated protein kinase unclassified drug animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell invasion cell migration cell viability controlled study female flow cytometry human human cell liver cell carcinoma mitochondrion mouse nonhuman signal transduction Western blotting
spellingShingle	acetylcysteine benzimidazole derivative caspase 3 methyl 2 (5 fluoro 2 hydroxyphenyl) 1h benzo[d]imidazole 5 carboxylate reactive oxygen metabolite stress activated protein kinase unclassified drug animal experiment animal model animal tissue antineoplastic activity apoptosis Article cancer inhibition cell invasion cell migration cell viability controlled study female flow cytometry human human cell liver cell carcinoma mitochondrion mouse nonhuman signal transduction Western blotting Dai X. Wang L. Deivasigamni A. Looi C.Y. Karthikeyan C. Trivedi P. Chinnathambi A. Alharbi S.A. Arfuso F. Dharmarajan A. Goh B.C. Hui K.M. Kumar A.P. Mustafa M.R. Sethi G. A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
description	10.18632/oncotarget.14606
author2	PHARMACY
author_facet	PHARMACY Dai X. Wang L. Deivasigamni A. Looi C.Y. Karthikeyan C. Trivedi P. Chinnathambi A. Alharbi S.A. Arfuso F. Dharmarajan A. Goh B.C. Hui K.M. Kumar A.P. Mustafa M.R. Sethi G.
format	Article
author	Dai X. Wang L. Deivasigamni A. Looi C.Y. Karthikeyan C. Trivedi P. Chinnathambi A. Alharbi S.A. Arfuso F. Dharmarajan A. Goh B.C. Hui K.M. Kumar A.P. Mustafa M.R. Sethi G.
author_sort	Dai X.
title	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
title_short	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
title_full	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
title_fullStr	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
title_full_unstemmed	A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
title_sort	novel benzimidazole derivative, mbic inhibits tumor growth and promotes apoptosis via activation of ros-dependent jnk signaling pathway in hepatocellular carcinoma
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/173807
_version_	1800914192743530496

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

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