Next-generation sequencing of translocation renal cell carcinoma reveals novel RNA splicing partners and frequent mutations of chromatin-remodeling Genes

• Main Authors: Malouf, G.G, Su, X, Yao, H, Gao, J, Xiong, L, He, Q, Compérat, E, Couturier, J, Molinié, V, Escudier, B, Camparo, P, Doss, D.J, Thompson, E.J, Khayat, D, Wood, C.G, Yu, W, Teh, B.T, Weinstein, J, Tannir, N.M
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Association for Cancer Research Inc. 2020
• Subjects: inhibitor of differentiation 2; microphthalmia associated transcription factor; phosphatidylinositol 3 kinase; transcription factor; transcription factor E; transforming growth factor beta1; unclassified drug; DNA helicase; INO80 protein, human; KHDRBS2 protein, human; KHSRP protein, human; messenger RNA; RED120 protein, human; RNA binding protein; transactivator protein; tumor marker; article; cancer incidence; cell cycle S phase; cell line; cell proliferation; chromatin assembly and disassembly; chromatin remodeling gene; controlled study; exome; gene; gene expression; gene silencing; gene technology; gene translocation; genetic association; genomics; human; human cell; INO80D gene; KHDRBS2 gene; KHSRP gene; kidney cancer; kidney carcinoma; LUC7L3 gene; mutation rate; next generation sequencing; priority journal; RNA sequence; RNA splicing; translocation renal cell carcinoma; apoptosis; cell cycle; enzyme immunoassay; gene expression regulation; genetics; genome-wide association study; high throughput sequencing; kidney tumor; metabolism; mutation; pathology; procedures; real time polymerase chain reaction; reverse transcription polymerase chain reaction; tumor cell culture; Western blotting; Apoptosis; Biomarkers, Tumor; Blotting, Western; Carcinoma, Renal Cell; Cell Cycle; Cell Proliferation; Chromatin Assembly and Disassembly; DNA Helicases; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; High-Throughput Nucleotide Sequencing; Humans; Immunoenzyme Techniques; Kidney Neoplasms; Mutation; Mutation Rate; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing; RNA, Messenger; RNA-Binding Proteins; Trans-Activators; Translocation, Genetic; Tumor Cells, Cultured
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175307
• Institution: National University of Singapore

10.1158/1078-0432.CCR-13-3036