Development of novel triazolo-thiadiazoles from heterogeneous "green" catalysis as protein tyrosine phosphatase 1B inhibitors

• Main Authors: Baburajeev, C.P, Dhananjaya Mohan, C, Ananda, H, Rangappa, S, Fuchs, J.E, Jagadish, S, Sivaraman Siveen, K, Chinnathambi, A, Ali Alharbi, S, Zayed, M.E, Zhang, J, Li, F, Sethi, G, Girish, K.S, Bender, A, Basappa, Rangappa, K.S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: 6-(2-benzylphenyl)-3-phenyl-(1,2,4)triazolo(3)(1,3,4)thiadiazole; antineoplastic agent; benzofuran derivative; BIRC5 protein, human; caspase 3; chromone derivative; cyclin D1; inhibitor of apoptosis protein; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl 2; protein tyrosine phosphatase 1B; PTPN1 protein, human; sanggenone C; STAT3 protein; STAT3 protein, human; thiadiazole derivative; triazole derivative; animal; antagonists and inhibitors; biosynthesis; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; cell motion; disease model; dose response; drug effects; female; G1 phase cell cycle checkpoint; Hep-G2 cell line; human; Liver Neoplasms; metabolism; molecular model; mouse; Neovascularization, Pathologic; pathology; rat; Sprague Dawley rat; structure activity relation; synthesis; tumor cell line; tumor invasion; umbilical vein endothelial cell; Animals; Antineoplastic Agents; Benzofurans; Caspase 3; Cell Line, Tumor; Cell Movement; Chromones; Cyclin D1; Disease Models, Animal; Dose-Response Relationship, Drug; Female; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitor of Apoptosis Proteins; Mice; Models, Molecular; Neoplasm Invasiveness; Poly(ADP-ribose) Polymerases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Structure-Activity Relationship; Thiadiazoles; Triazoles
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/175483
• Institution: National University of Singapore

10.1038/srep14195